Effects of prostaglandins on form deprivation myopia in the chick
N Jin, J Stjernschantz - Acta ophthalmologica Scandinavica, 2000 - Wiley Online Library
N Jin, J Stjernschantz
Acta ophthalmologica Scandinavica, 2000•Wiley Online LibraryPurpose: To investigate the possible role of endogenous prostaglandins in the development
of form deprivation myopia, as well as the effects of exogenous prostaglandins using
atropine as a positive control. Methods: Monocular form deprivation was accomplished by
mounting a translucent occluder on one eye of 2–3 day old chicks for 1–4 weeks. Ocular
occlusion for 1–2 weeks was used for pharmacological blocking experiments. The axial
length of the eye was measured by ultrasonography. Results: Indomethacin, administered …
of form deprivation myopia, as well as the effects of exogenous prostaglandins using
atropine as a positive control. Methods: Monocular form deprivation was accomplished by
mounting a translucent occluder on one eye of 2–3 day old chicks for 1–4 weeks. Ocular
occlusion for 1–2 weeks was used for pharmacological blocking experiments. The axial
length of the eye was measured by ultrasonography. Results: Indomethacin, administered …
Abstract
Purpose: To investigate the possible role of endogenous prostaglandins in the development of form deprivation myopia, as well as the effects of exogenous prostaglandins using atropine as a positive control.
Methods: Monocular form deprivation was accomplished by mounting a translucent occluder on one eye of 2–3 day old chicks for 1–4 weeks. Ocular occlusion for 1–2 weeks was used for pharmacological blocking experiments. The axial length of the eye was measured by ultrasonography.
Results: Indomethacin, administered intramuscularly, subconjunctivally or intra‐vitreally had no significant effect on myopia development. Exogenous PGE2, PGF2α and latanoprost acid administered subconjunctivally, or topically as isopropyl ester eyedrops had no statistically significant effect on the myopia development. However, PGF2α significantly (p<0.01) attenuated the development of myopia after intravitreal injection. The other two prostaglandins had no statistically significant effect.
Conclusions: Endogenous prostaglandins are unlikely to play a significant role in the development of form deprivation myopia in the chick. However, PGF2α suprisingly seems to retard the development of form deprivation myopia, but only when administered intravitreally. Whether the mechanism of the myopia retardation is direct or indirect remains unknown.
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